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. 2016 May 2;9:2575–2584. doi: 10.2147/OTT.S99671

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© 2016 Pathan et al. This work is published and licensed by Dove Medical Press Limited

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Superimposed binding pocket of GDP and GTP bound conformation of K-Ras protein.

Notes: GTP/GDP-binding pocket are divided into three subpockets: GBP (green), RBP (blue), and PBP (orange). The other extended cavity (purple) was found in inactive conformation. Light colors of the respective pocket are GTP-interacting residues and dark colors of the respective pocket are GDP-interacting residues; red arrows show the direction of residues’ movement from inactive to active state.

Abbreviations: GBP, guanine-binding pocket; GDP, guanosine diphosphate; GTP, guanosine triphosphate; PBP, phosphate-binding pocket; RBP, ribose-binding pocket.