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. 2016 May 9;7:80. doi: 10.3389/fgene.2016.00080

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Copyright © 2016 Rahmani, Zimmermann, Grill, Kennedy, Oberg, White, Poland and McKinney.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RIP-M module sizes for flu vaccine RNA-Seq co-expression network. Each of the 27 modules (from 4965 transcripts) is labeled by its most enriched immune system pathway (on the left) and by its hub gene (gene with highest within-module degree) on the right. Hard threshold τ = 0.2 of the absolute value of Pearson correlation was selected. The hard threshold choice was guided by the goal of having modules without extreme sizes, with a minimum size of 100 and maximum of 300. Parentheses in pathway names indicate source of annotation (Reactome, KEGG, NCI-PID, and BioCarta).