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. Author manuscript; available in PMC: 2016 May 9.
Published in final edited form as: J Am Chem Soc. 2015 Feb 3;137(6):2171–2174. doi: 10.1021/ja512012m

Figure 6.

Figure 6

Programmable micelle stability. (A) Plot of FRET ratios upon addition of antisense oligonucleotides. The perfectly complementary oligonucleotide (blue) disrupts the stability of diC18-UGGGU-ext micelles (orange), which looks similar to the diC18-UUUUU-ext micelles (purple). Antisense strands that do not disrupt the G-quadruplex (red) or contain a 3-base mutation (green) do not affect micelle stability. (B) Change in FRET ratio upon titration of the perfectly complementary antisense oligonucleotide. “Molar eq.” indicates molar equivalent of antisense oligonucleotide as compared to the concentration of the diC18-UGGGU-ext micelles.