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. Author manuscript; available in PMC: 2016 May 9.
Published in final edited form as: Nature. 2015 Jul 13;524(7563):47–53. doi: 10.1038/nature14664

Figure 3. Recurrent rearrangements generating oncogenic variants of TP73.

Figure 3

a, Genomic breakpoints identified by whole-genome sequencing were mapped to their chromosomal locations. Recurrent breakpoints (n > 6 samples) are highlighted in colours. b, Schematic representation of the TP73 locus (hg19) illustrating intragenic translocations. Coding and non-coding regions of the annotated exons are shown as black and white boxes, respectively. c, Schematic representation of exons encoding p73, p73Δex2, p73Δex2/3 and p73Δex10. d, Exon skipping events were assessed in the transcriptome data of samples with genomic translocations resulting in p73Δex2, p73Δex2/3 and p73Δex10 transcript variants. S02139 served as a reference sample without TP73 alterations. The expression of uncommon exon combinations is highlighted in red.