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. Author manuscript; available in PMC: 2016 May 9.
Published in final edited form as: ACS Chem Biol. 2016 Jan 6;11(3):547–553. doi: 10.1021/acschembio.5b00802

Figure 2.

Figure 2

Analysis of the phospho/methyl binding interface for K4me3 readers. (a) The structure of CHD1 DCD (orange) in complex with the H3K4me3 peptide (charcoal). CHD1 DCD is shown in a surface model with residues forming the K4me3 aromatic cage depicted as sticks. For clarity, only the side chains are shown. (b) The structure of the DIDO3 PHD finger (orange) in complex with the H3K4me3 peptide (white). The DIDO3 PHD finger is depicted as a surface model with residues involved in the stabilization of T3, K4me3, and T6 shown as sticks. Red dashes represent hydrogen bonds. PDB ID codes: 2B2W and 4L7X.