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. Author manuscript; available in PMC: 2016 May 9.
Published in final edited form as: Annu Rev Physiol. 2010;72:315–333. doi: 10.1146/annurev-physiol-021909-135801

Figure 2.

Figure 2

Intracellular prechylomicron transport. The assembly of prechylomicrons occurs in the lumen of the endoplasmic reticulum (ER). After their biogenesis in the ER lumen, prechylomicrons are packaged into specialized vesicles known as prechylomicron transport vesicles (PCTVs). The average diameter of the PCTVs is ~250 nm, which is sufficient to enclose chylomicron-sized particles. PCTVs bud off the ER membrane and move to and fuse with the cis-Golgi, delivering their prechylomicron cargo to the Golgi lumen. Nascent proteins are transported from the ER to the Golgi in coat protein complex II (COPII) vesicles. Their size ranges between ~55 and 70 nm. PCTVs bud from the ER membrane in the absence of COPII proteins, whereas the protein vesicles require the COPII machinery for their budding. After processing in the Golgi, mature chylomicrons are transported to the basolateral membrane via a separate vesicular system.

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