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. Author manuscript; available in PMC: 2016 May 9.
Published in final edited form as: Ann Rheum Dis. 2012 Jan 30;71(6):1049–1054. doi: 10.1136/annrheumdis-2011-200703

Figure 5.

Figure 5

Interleukin 6 (IL-6) concentration in supernatants of peripheral blood mononuclear cell cultures 24 h after incubation with medium, the proteinase-activated receptor 2 (PAR2) activating peptide SLIGKV-NH2 (100 μM) or lipopolysaccharide (LPS, 100 nM) in rheumatoid arthritis (RA, n=8), osteoarthritis (OA, n=6) or control (HC, n=6) groups. The basal concentration of IL-6 was substantially higher in the RA group compared with both the OA and HC groups (**p<0.002, one-way ANOVA). Patients with RA also generated significantly more IL-6 in response to SLIGKV-NH2 compared with both OA and HC groups (*p<0.05). Control subjects had a smaller response to LPS than the RA and OA groups (†p<0.05).