(A and B) Representative myocardium immunolabeled with plakoglobin (PLK) and connexin43 (Cx43) from vehicle- (Veh-) and SB216763-treated (SB2-treated) WT, Dsg2mut/mut, and JUP2157del2 mice. Scale bar: 20 μm. Images are representative of n = 4/genotype/treatment. (C and D) Western analysis of ventricular lysates probed for PLK, desmoplakin (DSP), and Cx43, normalized to GAPDH. Mean ± SEM, n = 4/genotype/treatment. P < 0.05 for SB2-treated mice vs. Veh-treated mice using 2-tailed paired t test.