Figure 7. SB216763 treatment improves response to exercise in Dsg2^mut/mut mice.

(A) Percentage survival of drug-treated exercised Dsg2^mut/mut and WT mice. Mean ± SEM, n values are shown. (B) Percentage ejection fraction and fractional shortening from exercised vehicle- (Veh-) and SB216763-treated (SB2-treated) Dsg2^mut/mut mice at 16 weeks of age. Mean ± SEM, n = 4/genotype/treatment. *P < 0.05 using 1-way ANOVA. (C) Myocardia immunolabeled with TUNEL from exercised Dsg2 mutant and WT mice treated with Veh or SB2. Scale bar: 20 μm. Images are representative of n = 4/genotype/treatment. (D) GSK3β immunolabeled myocardium. Images are representative of n = 4/genotype/treatment (white arrows, junctional signal for GSK3β; yellow arrowheads, absence of junctional signal for GSK3β). Scale bar: 20 μm. (E) Representative images from exercised drug-treated Dsg2^mut/mut and Dsg2^mut/+ mice immunostained for plakoglobin (PLK) and connexin43 (Cx43). Images are representative of n = 4/genotype/treatment. Scale bar: 20 μm.