Table 3.
MRI Coordinates
| Analysis | Peak coordinates | Peak location | Cluster size (μl) | Z-score | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| fMRI words > pseudowords | −34 | 28 | −12 | L inferior frontal gyrus | 29296 | 5.07 |
| −4 | 42 | 52 | L superior frontal gyrus | 7248 | 4.97 | |
| −32 | −40 | −24 | L fusiform gyrus | 2496 | 4.73 | |
| 10 | −80 | −26 | R calcarine sulcus | 2320 | 4 | |
| 30 | 26 | −10 | R inferior frontal gyrus | 4224 | 3.78 | |
| fMRI visual semantics | −30 | −36 | −12 | L parahippocampal gyrus / collateral sulcus | 2656 | 4.9 |
| fMRI abstract semantics | −50 | 20 | −12 | L superior temporal gyrus | 34984 | 5.38 |
| −38 | −90 | −2 | L middle occipital gyrus | 2832 | 4.62 | |
| 0 | 16 | 56 | L / R superior frontal gyrus | 7480 | 4.29 | |
| −4 | −20 | 10 | L thalamus | 4048 | 4.23 | |
| Patient atrophy | −29 | −5 | −34 | L fusiform gyrus | 93387 | 8.54 |
| 48 | −1 | −22 | R middle temporal gyrus | 10194 | 6.13 | |
| −17 | 41 | 11 | L cingulate gyrus | 1290 | 5.75 | |
| 54 | −44 | −13 | R inferior temporal gyrus | 910 | 5.44 | |
| −31 | 12 | 32 | L middle frontal gyrus | 166 | 5.27 | |
| −57 | −57 | −6 | L inferior temporal gyrus | 214 | 5.15 | |
| −15 | 15 | 35 | L cingulate gyrus | 53 | 5.08 | |
| Patient regression analysis | −28 | −32 | −7 | L parahippocampal gyrus / hippocampus | 2660 | 4.11 |
The results for “fMRI words > pseudowords” come from the contrast of word-association trials with pseudoword letter-matching trials. The results for “fMRI visual semantics” reflect the positive effects of the parametric modulator for visual association strength. The results for “fMRI abstract semantics” reflect the negative effects of the parametric modulator for visual association strength. The results for “Patient atrophy” are from the contrast of gray matter density in patients relative to controls. The results for the “Patient regression analysis” are from the regression of gray matter density and performance on visual relative to abstract concepts.