FIGURE 2.

Schematic of the elements identified in the ID in this study and their associated mutations. Top, CARD11 domain structure is depicted with the relative location of repressive and activating elements in the ID. The LATCH domain lies between the CARD and the coiled coil, L3 between PDZ and Src homology 3, and L4 between Src homology 3 and GUK. Bottom, amino acid sequence of the ID is depicted. Repressive and activating elements are indicated in red and green, respectively. Mutations used in the study are indicated in blue.