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Effect of oncogenic mutations on RE binding to ΔID
| Relative bindinga |
|||
|---|---|---|---|
| GST-RE14 | GST-RE24 | GST-RE34 | |
| ΔID | 1.00 | 1.00 | 1.00 |
| ΔID-C49Y | 0.33 | 0.06 | 0.26 |
| ΔID-F97Y | 0.46 | 0.05 | 0.63 |
| ΔID-G123D | 0.12 | 0.05 | 0.16 |
| ΔID-F130I | 0.38 | 0.20 | 0.15 |
| ΔID-L232LI | 0.23 | 0.73 | 0.53 |
a The relative binding in each column was calculated by determining the bound/input ratio for each CARD11 variant and normalizing to that observed with the ΔID after densitometric analysis of the blots in Fig. 7.
