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TIR-199 inhibited the proteasome activity in human embryonic kidney cells HEK-293 cells using a proteasome sensor cell transfection assay. A, HEK-293 cells transfected with the ZsProSensor-1 plasmid were treated with the indicated concentrations of TIR-199 and BTZ and quantified for GFP expression as a marker for proteasome inhibition. B, fluorescent microscope images of GFP-expressing cells treated with TIR-199, BTZ, or control, after 24 h of exposure. Error bars, S.E.
