TABLE 5.

In vivo acute toxicity study

The MTD of TIR-199 was determined in athymic nude female mice as described under “Experimental Procedures.” TIR-199 was tested at three doses (intraperitoneal single injection), and an MTD of 25 mg/kg was determined. Groups 1–3; n = 1/group. Experiments were performed at the NCI-DTP. IP, intraperitoneal.

Group	Dose (IP)	Schedule	Death days	Survival/Total (day 19)
1	12.5 mg/kg/dose	Daily × 1, day 0		1/1
2	25.0 mg/kg/dose	Daily × 1, day 0		1/1
3	50.0 mg/kg/dose	Daily × 1, day 0	2	0/1