FIGURE 4.

Reduced targeting of LIMP-2/SCARB2 to lamellar bodies in pearl mice. Representative immunoblots (A) with densitometry (B) for LIMP-2/SCARB2, PRDX6, SP-A, and SP-B using lamellar body fractions (LB; 5 μg of protein) from wild type (WT) and pearl (pe) mice (n = 4 samples prepared from 2 to 4 mice each; mean ± S.D.). C, immunolocalization of LIMP-2/SCARB2 with LAMP1 identifying lamellar bodies in isolated alveolar type 2 cells from WT and pearl mice (representative of two experiments; bars represent 5 μm).