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Schematic of the pathways elucidated in this work. Under LSS, p47phox and NOX2 complex, causing a modest increase in H2O2, which results in activation of eNOS, a consequent increase in NO production, and a decline in superoxide levels. Under OSS, NOX1 and NOXO1 complex, resulting in uncoupling of eNOS. This leads to increased production of superoxide and a decrease in NO bioavailability.
