FIGURE 10.

Expression levels of IL23Rα-protective variants are lower in NIDDK cell lines. Western blotting of cell lysates from NIDDK cell lines shows the expression of IL23Rα and its variants R381Q and V362I at endogenous levels using antibodies specific to IL23Rα. IL12Rβ1 antibody was used for the loading control. Representative Western blot from three independent experiments is shown, and cells that are homozygous and heterozygous to the IL23Rα allele are described as homo and hetero, respectively.