FIGURE 1.

The effect of intraileal propionate infusion on glucose kinetics. A, schematic representation of the working hypothesis (left) and experimental procedure and pancreatic (basal insulin) euglycemic clamp protocol (right). SRIF, somatostatin. B–E, the glucose infusion rate (B), rate of GP (C), % suppression of GP (D), and glucose uptake (E) during the pancreatic clamp in rats with intraduodenal saline (Sal; n = 6) or propionate (Prop; n = 7) infusions, or intravenous (i.v.; n = 6) propionate infusion. Values are shown as mean ± S.E. **, p < 0.01; ***, p < 0.001, versus all other groups as determined by ANOVA with Tukey's post hoc test.