FIGURE 6.

Differential effect of genotype (WT versus Parp1^−/−) and treatment (H₂O) versus 3% DSS on colonic gene expression. A, data were normalized and filtered as in Fig. 2 and statistically analyzed for transcript IDs that statistically differed between H₂O- and DSS-treated WT mice (moderated t test p ≤ 0.05, -fold change cutoff of ≥2.0). 755 transcript IDs identified in WT mice are plotted. B, the same 755 transcript IDs were selected and plotted with respective normalized values derived from H₂O- and DSS-treated Parp1^−/− mice.