FIGURE 5.

IL-15:IL-15Rα-bearing nanoparticles stimulate cross-priming of human antigen-specific CD8⁺ T cells by DCs. a, nanoparticles encapsulating a MART-1-derived 26-mer peptide were loaded into human HLA-A2⁺ PBMC-derived DCs and used to stimulate MART-1-specific DMF-5 T cells. b, the adjuvant effect of the nanoparticle formulations was evaluated by IFN-γ production from DMF-5 cells after 72 h in culture with DCs. Data were analyzed by a one-way ANOVA and a Tukey post-hoc test. *** indicates a significance level of p ≤ 0.001. PBMC, peripheral blood-derived mononuclear cells.