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Gibbs free energy change in cancer cells and the relative activities of PFK1, PKM2, and LDH to HK at physiological substrate concentrations. A, standard and actual change of Gibbs free energy in cancer cells. The standard change of Gibbs free energy ΔG′0298 K is from Ref. 30; the actual change of Gibbs free energy ΔG is calculated as described as “Experimental Procedures.” B, activities of enzymes relative to HK, which is defined as 1. Data are mean ± S.D., n = 3.
