FIGURE 11.
MMR in the presence of CAF-1-, ASF1A-H3-H4-, PCNA-, and RFC-dependent histone (H3-H4)2 tetramer deposition. The findings described in this work are consistent with the model in which a subset of human MMR events coincides with CAF-1-, ASF1A-H3-H4-, PCNA-, and RFC-dependent deposition of the histone (H3-H4)2 tetramers onto the newly synthesized DNA. The model is in part based on the results of previous studies of human MMR (27, 33, 35, 39, 40, 42–44, 56). The model also depicts that MutSα interacts with ASF1A-H3-H4. As described under “Discussion,” this interaction may be important to facilitate MMR in the presence of CAF-1-, ASF1A-H3-H4-, PCNA-, and RFC-dependent histone (H3-H4)2 tetramer deposition. HE, holoenzyme.