Table. Clinical laboratory results for 15-year-old girl with sickle cell disease who died of Zika virus infection, Colombia*.
| Laboratory test | Baseline value | Value at hospitalization (Malambo) | Value 24 h later (ICU, Barranquilla) |
|---|---|---|---|
| Leukocyte count, × 109 cells/L | 10.00 | 8.23 | ND |
| Hemoglobin level, g/dL | 7.00 | 8.10 | 4.20 |
| Hematocrit, % | 28.00 | 25.00 | 13.00 |
| MCV, fL/erythrocyte | 73.00 | 73.00 | ND |
| Reticulocytes, % | 1.00 | 1.00 | ND |
| Total bilirubin, mg/dL | ND | 2.97 | ND |
| Direct bilirubin, mg/dL | ND | 1.67 | ND |
| Platelet count/mL |
ND |
54,000.00 |
76,000.00 |
| PT, s | ND | ND | 33.3 (control 13.10) |
| aPTT, s | ND | ND | 45.0 (control 29.80) |
| ALT, mg/dL | ND | ND | 2,245.00 |
| AST, mg/dL | ND | ND | 3,215.00 |
| LDH , IU/L |
ND |
ND |
441.00 |
| Alkaline hemoglobin electrophoresis, % | |||
| HbS | ND | ND | 62.50 |
| HbC–E | ND | ND | 37.50 |
| HbF |
ND |
ND |
0.00 |
| Malaria thick and thin blood smears† | Not done | Not done | – |
| HIV-1 and HIV-2 ELISA† | Not done | Not done | – |
| MAT for Leptospira spp.† |
Not done |
Not done |
– |
| RT-PCR for DENV† | Not done | Not done | – |
| RT-PCR for CHIKV† | Not done | Not done | – |
| RT-PCR for YFV† | Not done | Not done | – |
| RT-PCR for ZIKV† | Not done | Not done | + |
*ICU, intensive care unit; ND, not determined; MCV, mean corpuscular volume; PT, prothrombin time; aPTT, activated partial thromboplastin time; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; Hb, hemoglobin; –, negative; MAT; microscopic agglutination test; RT-PCR, reverse transcription PCR; DENV, dengue virus; CHIKV, chikungunya virus; YFV, yellow fever virus; ZIKV, Zika virus; +, positive. †Blood samples were obtained 5 days after illness onset. These tests were performed at the National Reference Laboratory of the National Institute of Health, Bogotá, Colombia.