. 2016 May 3;10:1489–1500. doi: 10.2147/DDDT.S88587

Table 2.

Cellular antiproliferative activity

Compounds	Cellular antiproliferative activity (IC₅₀, μM)
Compounds	Hela229	H460	Hct116	B16-F10	HL7702
TKI258	>50	15.79±1.20	3.05±0.58	29.6±2.13	32.79±2.38
A1	>50	13.74±6.97	12.31±4.55^*	4.27±1.09^**	>100
A2	>50	16.38±1.14	7.17±2.01	5.65±1.29^**	41.50±7.56^*
A3	>50	9.62±0.50^*	12.34±2.39^*	7.61±1.25^**	78.98±5.28^***
A4	>50	37.39±9.27^**	21.34±3.16^**	4.96±1.85^**	67.91±1.94^***
A5	2.89±0.24^***	0.46±0.35^**	0.27±0.22	0.058±0.043^**	>100
A6	>50	>50	>50	11.59±1.53^*	>100
A7	46.16±0.45	>50	31.07±3.66^**	12.48±3.23^*	83.24±8.12^***
A8	>50	>50	>50	9.56±1.39^**	>100
A9	25.31±0.83^**	>50	24.95±3.32^**	5.83±0.07^**	>100
A10	>50	>50	>50	40.50±5.63	68.24±5.96^***
A11	>50	>50	>50	8.76±0.36^**	>100
A12	12.89±0.74^**	14.6±3.5	12.7±1.22^*	10.58±0.73^*	>100
A13	21.31±2.63^**	20.17±1.79	17.94±3.90^*	7.09±2.62^**	>100
A14	>50	>50	>50	13.0±1.12^*	>100
B1	19.09±1.47^**	4.14±1.07^**	7.04±1.30	0.79±0.27^**	>100
B2	11.82±2.43^**	1.08±0.73^**	4.06±2.72	9.95±1.75^**	>100
B3	27.49±4.85^**	>50	19.48±5.91^**	18.88±1.78^*	48.95±1.31^**
B4	43.25±0.47	13.8±0.26	5.28±2.11	0.03±0.02^**	>100
B5	14.6±0.53^**	5.78±0.78^**	7.62±1.52	6.64±0.08^**	53.66±2.17^**
C1	>50	14.6±0.27	>50	14.20±0.21^*	>100
C2	>50	18.1±0.45	>50	3.93±0.37^**	>100
C3	>50	21.49±1.34	>50	16.85±1.31^*	>100
C4	>50	16.81±2.84	>50	5.56±1.39^**	>100
C5	>50	26.09±9.64	16.07±3.95^*	32.87±3.85	35.76±2.17
D1	>50	34.03±14.34^**	18.32±3.12^**	17.86±1.59^*	40.23±1.85^*
D2	12.26±2.28^**	19.5±0.44	11.03±2.05^*	1.18±0.24^**	90.23±5.23^***
D3	12.39±0.51^**	11.60±0.39	1.11±2.71	0.51±0.08^**	>100

Notes: Each value represents the mean ± SEM from three experiments significantly different from TKI258 at

P<0.05,

^**

P≤0.005, and

^***

P≤0.001 (by Student’s t-test).

Abbreviation: SEM, standard error of the mean.