Table 3.
Determination of in vivo infectivity of mHIVenv and serial 10× dilutions of non-inactivated PHIV inoculated in the implants of SCID-hu Thy/Liv mice.
Group | Mice (N) | TCID50 per implant | Number infected | p24 (pg/106 cells) | Total cell yield (×106) |
---|---|---|---|---|---|
Aa | 4 | 430 | 3/3 | 630 ± 93 | 150 ± 32 |
Bb | 4 | 43 | 3/3 | 750 ± 140 | 110 ± 38 |
C | 4 | 4.3 | 4/4 | 460 ± 150 | 210 ± 45 |
D | 4 | 0.43 | 4/4 | 470 ± 110 | 230 ± 84 |
E | 4 | Mock infected | 0/4 | Negative | 680 ± 160 |
F | 10 | mHIVenv | 0/10 | Negative | 90 ± 12 |
Group A: Mouse #4 died (cause unknown).
Group B: Mouse #6 no implant found at termination.