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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: J Mol Cell Cardiol. 2016 Mar 23;94:72–81. doi: 10.1016/j.yjmcc.2016.03.008

Fig. 1. Reconstruction of the cardiac fibroblast signaling network.

Fig. 1

Each of the 91 nodes represents a gene product, modification of a gene product, or cell process in the model. Each arrow indicates a reaction based on experimental data of activation or inhibition from cardiac fibroblasts or a fibroblast-related cell line (142 reactions from 177 papers). Where shown, some reactions combine the influence of multiple reactants via AND gate logic. Multiple reactions affecting the same product are combined using OR gate logic.