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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: J Mol Cell Cardiol. 2016 Mar 23;94:72–81. doi: 10.1016/j.yjmcc.2016.03.008

Fig. 2. Example of model validation with combined stimuli.

Fig. 2

(A) Predicted dynamics of selected outputs in response to TGFβ, followed by a combined TGFβ + forskolin stimulus. Full dynamic prediction shown in Fig. S1 (B) The model prediction is compared to independent experimental data from Lu et al 2013 [17], showing the attenuation of collagen I mRNA by forskolin treatment. The model prediction is expressed as percent of maximal mRNA level. Experimental collagen mRNA is relative to the initial measurement at day 0.