Table 1. Model-predicted functional modules.

The members of each functional module identified using k-means clustering of the high TGFβ sensitivity analysis.

Module	Members
PDGF	PDGF, PDGFR, TNFα, TNFαR, p38, PP1, JNK, abl, cmyc
Autocrine	ROS, ET1, ETAR, DAG, TRPC, latentTGFβ, Ca, calcineurin, NFAT, ERK, EDAFN, AP1, TIMP1, TIMP2
Migration	Migration, proMMP14, proMMP2, MMP2, MMP14
Natriuretic	NP, NPRA, cGMP, PKG, proliferation
Cytokine	smad7, BAMBI, IL6, gp130, STAT, IL1, IL1RI, NFκB, proMMP1, MMP1, fibronectin
Mechanical	PKC, mechanical stimulus, β1int, Rho, ROCK, Rac1, MEKK1, FAK, Factin, FA, SRF
TGFβ	ACE, NOX, TGFβ, TGFβ-R, PI3K, Akt, TRAF, ASK1, MKK3, MKK4
Angiotensin	AngII, AT1R, AGT, Ras, Raf, MEK1, proMMP9, MMP9
Beta Adrenergic	NE, BAR, forskolin, AC, cAMP, PKA, CREB, epac
Fibrosis	CBP, smad3, CTGF, αSMA, PAI1, periostin, CImRNA, CIIImRNA, CI, CIII