Table 2. Pathologic features comparing between PSP with and without cerebellar ataxia.

	Ataxia (43)	No ataxia (61)	P value
Demographic
Gender, % male	23/43 (52%)	40/61 (65%)	0.255 a
Age at death	74.8 ± 9.0	73.9 ± 7.4	0.585 b
Pathologic features
Brain weight (g)	1120 (1060, 1195)	1200 (1110, 1320)	0.011 c
Braak NFT stage	III (II, III)	II (I, III)	0.069 c
Thal amyloid phase	1.0 (0, 3)	0 (0, 3)	0.200 c
Ratio of Purkinje tau positive	27/42 (64%)	36/60 (60%)	0.817 a
Number of pretangles in Purkinje cell layer	1.0 (0, 2)	1.0 (0, 3)	0.910 c
Pretangles linear density (cells/mm)	3.6 (3, 4)	3.7 (3, 4)	0.421 c
Semi-quantitative analysis
Coiled bodies in cerebellar white matter	2.0 (1, 3)	2.0 (1, 3)	0.860 c
Tau threads in cerebellar white matter	2.0 (1, 3)	1.0 (1, 2)	0.496 c
Coiled bodies in dentate nucleus	1.0 (0, 1)	1.0 (0, 1)	0.732 c
Tau threads in dentate nucleus	2.0 (1, 2)	2.0 (1, 2)	0.332 c
Pretangles/NFT in dentate nucleus	2.0 (2, 3)	3.0 (2, 3)	0.335 c
Pretangles/NFT in pontine base	3.0 (2, 3)	3.0 (2, 3)	0.477 c
Pretangles/NFT in inferior olivary nucleus	2.0 (1, 2)	2.0 (1, 2)	0.192 c
Genetic analysis
MAPT: H1H1 genotype	36/38 (95%)	42/49 (86%)	0.170 d
MAPT: H1H2 genotype	2/38 (5%)	7/49 (14%)	0.170 d
APOE: ε4 genotype	10/39 (26%)	12/53 (23%)	0.739 a

Data are displayed as mean ± SD or median (25^th, 75^th range) as appropriate. Abbreviations: PSP, progressive supranuclear palsy; PSP-C, PSP, progressive supranuclear palsy with predominant cerebellar ataxia; NFT, neurofibrillary tangles;

^aChi-square test,

^bt-test,

^cMann-Whitney rank sum test,

^dFisher exact test