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. Author manuscript; available in PMC: 2017 May 6.

Published in final edited form as: ChemMedChem. 2016 Mar 15;11(9):980–989. doi: 10.1002/cmdc.201600090

Scheme 1 — Synthesis of: a) aromatic walls 3 and 5, and b) acyclic CB[n]-type molecular containers M2C2 and M2C4. Conditions: a) K₂CO₃, 18-crown-6, BrCH₂CH₂Br, CH₃CN, 70 °C; b) Na₂SO₃ in H₂O/DMF (1:1),100 °C, 81%; c) butanesultone (4), NaOH, H₂O, dioxane, RT, 26%; d) CF₃CO₂H/Ac₂O (1:1), 70 °C, (M2C2, 58%; M2C4 43%).