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. Author manuscript; available in PMC: 2016 May 28.
Published in final edited form as: J Control Release. 2016 Apr 7;230:79–87. doi: 10.1016/j.jconrel.2016.04.009

Figure 9.

Figure 9

LGG encapsulated in pectin hydrogel beads prevents DSS-induced colitis in mice. Colonic injury and colitis were induced by treating mice with 3% DSS in drinking water for 4 days. Mice were gavaged with 108 of non-capsulated LGG in water or encapsulated LGG/day, starting 3 days before DSS treatment until the end of the experiment. Beads only were used as control for encapsulated LGG. (A) Paraffin-embedded colon sections were stained with H&E for light microscopic assessment of epithelial damage. Original magnification: 10X. (B) Injury and inflammation scores are shown. (C) MPO activity in the colonic tissue was detected. (D) Colonic tissues were isolated for real-time PCR analysis of the indicated cytokine mRNAs. The average cytokine mRNA expression level in the water group was set as 1, and mRNA expression levels in other groups were compared to obtain the fold change. * p < 0.05 compared to the water group, # P < 0.05 compared with DSS, DSS with non-encapsulated LGG-treated and bead only treated groups. N=5 in each group in D.