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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Med Sci Sports Exerc. 2016 Mar;48(3):439–448. doi: 10.1249/MSS.0000000000000790

Table 4. Geometric means for urinary estrogens and estrogen metabolites (pmol/mg creatinine) by sedentary behavior, adjusted for light and moderate-to-vigorous activity.

Estrogen Metabolite (EM) Measure Sedentary Behavior2 (average min/day) P-trend3
≤ 423.0 424.5-505.5 >505.57
Total EM 30.61 31.22 39.27 0.11
Parent estrogens 5.33 5.52 8.19 0.04
 Estrone 4.06 4.22 6.28 0.04
 Estradiol 1.12 1.10 1.69 0.04
2-Hydroxylation pathway 9.80 10.18 12.44 0.09
2-Pathway catechols 7.88 8.05 9.88 0.13
 2-Hydroxyestrone 6.27 6.43 7.90 0.14
 2-Hydroxyestradiol 1.55 1.55 1.90 0.12
2-Pathway methylated catechols 1.76 1.94 2.34 0.02
 2-Methoxyestrone 1.02 1.11 1.34 0.03
 2-Methoxyestradiol 0.36 0.43 0.53 0.002
 2-Hydroxyestrone-3-methyl-ether 0.33 0.35 0.42 0.06
4-Hydroxylation pathway 1.30 1.37 1.66 0.07
4-Pathway catechol: 4-hydroxyestrone 0.98 1.02 1.25 0.11
4-Pathway methylated catechols 0.28 0.31 0.37 0.02
 4-Methoxyestrone 0.19 0.21 0.25 0.04
 4-Methoxyestradiol 0.08 0.09 0.11 0.01
16-Hydroxylation pathway 13.40 13.29 15.90 0.25
 16α-Hydroxyestrone 2.53 2.47 2.88 0.40
 Estriol 6.23 6.14 7.45 0.25
 17-Epiestriol 0.38 0.39 0.45 0.28
 16-Ketoestradiol 3.27 3.28 3.97 0.18
 16-Epiestriol 0.66 0.72 0.81 0.13
Metabolic pathway ratios
 2-pathway / parent estrogens 1.84 1.84 1.52 0.07
 2-pathway catechols / parent estrogens 1.48 1.46 1.21 0.06
 2-pathway methylated / parent estrogens 0.33 0.35 0.29 0.28
 4-pathway catechol / parent estrogens 0.18 0.19 0.15 0.09
 4-pathway methylated / parent estrogens 0.05 0.06 0.04 0.27
 4-pathway / parent estrogens 0.24 0.25 0.20 0.10
 16-pathway / parent estrogens 2.51 2.41 1.94 0.01
 2-pathway / 16-pathway 0.73 0.77 0.78 0.11
 2-hydroxyestrone / 16α-hydroxyestrone 2.48 2.60 2.74 0.04
 4-pathway / 2-pathway 0.13 0.13 0.13 0.62
 4-pathway / 16-pathway 0.10 0.10 0.10 0.10
 4-pathway catechol / 4-pathway methylated 3.52 3.29 3.41 0.70
 2-pathway catechol / 2-pathway methylated 4.47 4.16 4.22 0.43
1

Adjusted for age, BMI, light and moderate-to-vigorous activity and wear time

2

Sedentary behavior (counts <100)

3

P-trend <0.05 are bolded