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. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039

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Copyright © 2016 Bluhm, Schneider, Schäfer, Piantavigna, Goldbach, Knappe, Seibel, Martin, Veldhuizen and Hoffmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electron microscopy images of P. aeruginosa DSM 1117 incubated with Api137 (A), Api795 (B), and Api794 (C) at concentrations corresponding to 0.25 × MIC, MIC, and 4 × MIC for 1 h using cell densities of 5 × 10⁸ CFU/mL. Black bars represent 500 nm. Morphological changes are indicated with arrows: dissociated fragments (blue), small vesicle release (green), large vesicle release (dark green), relocalized DNA (orange), slightly clustered ribosomes (red), and extremely clustered ribosomes (dark red).