Table 1.

Peptide sequences and minimal inhibitory concentrations (MICs) of Api137 and its new analogs.

Code	Sequence	MIC [μg/mL]
		P. aeruginosa
		DSM 1117	DSM 3227	DSM 9644	DSM 1117	DSM 3227	DSM 9644	E. coli ATCC 25922	K. pneumoniae DSM 681
		50% MHB			100% MHB			TSB
Api137	guONNRPVYIPRPRPPHPRL	256	>256	256	>256	>256	>256	2	16
Api755	guOIORPVYOPRPRPPHPRL	16	64	16	128	256	128	8	8
Api760	guOWORPVYOPRPRPPHPRL	16	32	8	128	256	128	8	8
Api793	guO(WO)2RPVYOPRPRPPHPRL	16	16	8	64	256	64	8	16
Api794	guO(WO)3RPVYOPRPRPPHPRL	16	16	16	32	128	16	16	32
Api795	guO(IO)2RPVYOPRPRPPHPRL	8	16	8	32	256	128	8	8
Api796	GuO(IO)3RPVYOPRPRPPHPRL	8	16	16	64	128	128	8	16

Activities were determined against three strains of P. aeruginosa in 50% and 100% MHB and one strain of E. coli and K. pneumoniae in TSB.