Table 2.

Selected TRAPs expressed in mast cells and their function.

Gene symbol	Most used aliases	KO	Phenotype of KO mice: general/in mast cells
LAT	LAT1, pp36	Zhang et al., 1999	Defect in T-cell development—no mature T cells (Zhang et al., 1999)/reduced degranulation, Ca2+ release and cytokine production, PSA (Saitoh et al., 2000)
LAT2	LAB, NTAL, WBSCR15, WBSCR5	Volná et al., 2004; Zhu et al., 2004	Increased levels of natural antibodies and humoral response (Wang et al., 2005)/increased degranulation, Ca2+ release, cytokine production, PCA (Volná et al., 2004; Zhu et al., 2004), and chemotaxis (Tumová et al., 2010)
PAG1	PAG, CBP	Draberova et al., 2014	No visible changes in phenotype/reduced degranulation, Ca2+ release, cytokine production, chemotaxis, PCA (Draberova et al., 2014)
LAX1	LAX	Zhu et al., 2005a	Reduction in CD23 expression on mature B cells, spontaneous germinal center formation, hyper-responsiveness in T and B lymphocytes (Zhu et al., 2005a)/enhanced degranulation, cytokine production, cell survival (Zhu et al., 2006)
GAPT		Liu and Zhang, 2008	Increased B-cell proliferation and amount of Abs (Liu and Zhang, 2008)