Table 6.

Connection profile of the right anterior insula ICCp cluster associated with age.

Targets	Effect size	T(184)	p-unc	p-FDR
C13_antDMN_lANG	0.07	4.7	< 0.001	< 0.001	Long Distance	Parietal
All_ICCpCluster_LeftSFG	0.06	4.25	< 0.001	0.002
C02_CON_rACC	−0.06	−3.98	< 0.001	0.003
C13_antDMN_lPCC	0.05	3.73	< 0.001	0.006	Long Distance	Parietal
C28_postDMN_medSFG	0.05	3.44	< 0.001	0.014
C13_antDMN_lMedSFG	0.05	3.31	0.001	0.017
C04_VAN_rMFG	−0.05	−3.24	0.001	0.017
C13_antDMN_rPCC	0.04	3.24	0.001	0.017	Long Distance	Parietal
C13_antDMN_rANG	0.05	3.2	0.002	0.017	Long Distance	Parietal
C18_LANG_lMTG	0.04	3.15	0.002	0.018	Long Distance	Temporal
C28_postDMN_lMOC	0.05	3.07	0.002	0.021	Long Distance	Occipital
C18_LANG_lPrecun	0.04	2.93	0.004	0.03	Long Distance	Parietal
C13_antDMN_lCrus2	0.04	2.91	0.004	0.03	Long Distance	Cerebellum
C14_VIS_rCalc	−0.04	−2.84	0.005	0.033	Long Distance	Occipital
C18_LANG_lCrus2	0.04	2.83	0.005	0.033	Long Distance	Cerebellum
C04_VAN_rPrecun	−0.04	−2.8	0.006	0.034	Long Distance	Parietal
C13_antDMN_lMTG	0.04	2.71	0.007	0.04	Long Distance	Temporal
C26_DAN_lSMG	−0.04	−2.68	0.008	0.04	Long Distance	Parietal
C13_antDMN_rCrus1	0.04	2.68	0.008	0.04	Long Distance	cerebellum
C18_LANG_rPrecun	0.04	2.67	0.008	0.04	Long Distance	Parietal
C04_VAN_bMCC	−0.04	−2.64	0.009	0.041
C13_antDMN_rMedSFG	0.04	2.6	0.01	0.044
C05_AUD_rThal	−0.03	−2.57	0.011	0.044	Long Distance	Subcortical
C26_DAN_rPrecun	−0.03	−2.57	0.011	0.044	Long Distance	Parietal

The table lists the connections of the right insula ICCp cluster and the corresponding target ROIs that exhibit an age-related reduction in connection strength or an anti-correlation of age and connection strength [p < 0.05 FDR corrected (two-sided)], the effect sizes, and the t-values. All connections to regions beyond the frontal cortex are defined as long-distance connections and the corresponding target region is specified in the last column of the table.