Table 4.
Regions with increase degree centrality in patients with ALS compared with healthy controls in the binarizednetworks.
| Areas | Voxel sizea | Voxels structure (BA)b | Peak MNI coordinateb | Peak intensity (T value) | Peak MNI coordinate region | ||
|---|---|---|---|---|---|---|---|
| X | Y | Z | |||||
| Area 1 | 194 | –27 | –69 | –48 | 4.4222 | Left Cerebellum Posterior Lobe7 | |
| Area 2 | 41 | 33 | –69 | –42 | 3.5008 | RightCerebellumCrus | |
| Area 3 | 108 | –3 | –87 | –36 | 4.6621 | Left CerebellumCrus 2 | |
| Area 4 | 18 | –15 | –75 | –27 | 3.679 | Left CerebellumCrus 1 | |
| Area 5 | 37 | BA11 | 24 | 42 | –21 | 3.8082 | Right Middle Orbital Frontal gyrus |
| Area 6 | 85 | BA18/19 | –24 | –96 | –18 | 3.997 | Left Lingual gyrus |
| Area 7 | 25 | BA18 | 36 | –96 | –9 | 3.7465 | Right inferior Occipital gyrus |
| Area 8 | 21 | BA18 | 12 | –102 | –6 | 3.0777 | Right Lingual gyrus |
| Area 21 | 38 | BA8/9 | 12 | 45 | 54 | 3.7879 | Superior Frontal gyrus |
a
Statistical significance was set at a voxel-wise p < 0.01, in conjunction with cluster wise AlphaSim (rmm = 5, clusters = 18) to correct for multiple comparisons.
b
BA, Brodmann area; MNI, Montreal Neurological Institute.