Table 5.
Regions with decrease degree centrality in patients with ALS compared with healthy controls in the binarized networks.
| Areas | Voxel sizea | Voxels structure (BA)b | Peak MNI coordinateb | Peak intensity (T value) | Peak MNI coordinate region | ||
|---|---|---|---|---|---|---|---|
| X | Y | Z | |||||
| Area 9 | 42 | BA18/37 | –21 | –51 | –3 | –4.3062 | Left Lingual gyrus, extent to fusiform gyrus |
| Area 10 | 81 | BA17/18/37 | 18 | –48 | 3 | –4.3412 | Right Calcarine gyrus, extent to Lingual gyrus, and fusiform gyrus |
| Area 11 | 19 | BA22 | –54 | –27 | –3 | –4.2576 | Left Middle Temporal |
| Area 12 | 20 | BA45 | 60 | 27 | 6 | –3.6089 | Right Triangular Part of inferior Frontal gyrus |
| Area 13 | 115 | BA48 | 33 | –18 | 21 | –4.757 | Right Insula gyrus |
| Area 14 | 45 | BA48 | –36 | –27 | 12 | –4.3269 | Left Heschl gyrus |
| Area 15 | 22 | BA48 | –66 | –48 | 24 | –4.2694 | Left SupraMarginal gyrus |
| Area 16 | 166 | BA3/4/6 | 42 | –12 | 27 | –4.5985 | Right Precentral gyrus, extent to Postcentral gyrus |
| Area 17 | 42 | BA23 | –9 | –21 | 45 | –4.1167 | Left Middle Cingulum gyrus |
| Area 18 | 67 | BA3/4/6 | –45 | –15 | 51 | –5.2347 | Left Postcentral gyrus extent to Precentral gyrus |
| Area 19 | 19 | BA4/23 | 6 | –18 | 57 | –3.7851 | Right Supplement Motor Area, extent to Precentral gyrus |
| Area 20 | 39 | BA5 | –9 | –39 | 60 | –4.3001 | Left Precuneus gyrus |
| Area 22 | 24 | BA4 | –6 | –27 | 60 | –3.8749 | Left Paracentral gyrus |
| Area 23 | 37 | BA4 | 15 | –21 | 72 | –3.8176 | Right Precentral gyrus |
a
Statistical significance was set at a voxel-wise p < 0.01, in conjunction with cluster wise AlphaSim (rmm = 5, clusters = 18) to correct for multiple comparisons.
b
BA, Brodmann area; MNI, Montreal Neurological Institute.