Skip to main content
. 2016 May;186(5):1166–1179. doi: 10.1016/j.ajpath.2015.12.015

Figure 7.

Figure 7

Despite reduced M cell induction, clinical course of disease is not reduced by anti–tumor necrosis factor-α (TNF-α) treatment. A: Under the shown conditions, weight loss is not abrogated by treatment. B: Whole tissue imaging of colon shows persistence of dsRed signal despite anti–TNF-α treatment, probably because of persistent dsRed+ neutrophil infiltration. C: Histopathology is not significantly affected by anti–TNF-α treatment. Hematoxylin and eosin staining shows inflammation, ulceration, and loss of crypt architecture (arrows) in dextran sodium sulfate (DSS)–treated mice. D: Blinded pathology scoring indicates severe pathology in anti–TNF-α–treated animals compared with control. Data were assessed by unpaired t-test. Data represent the means ± SEM (D). n = 3 mice per group (D). ∗P ≤ 0.05, ∗∗P ≤ 0.01, and ∗∗∗P ≤ 0.001. Ctrl, control.