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. 2016 May;186(5):1166–1179. doi: 10.1016/j.ajpath.2015.12.015

Figure 8.

Figure 8

Intestinal inflammation caused by Citrobacter rodentium induces colonic M cells. A: Schematic depiction of C. rodentium infection used in this study. B: Representative scanning electron micrograph further confirming the induction of colonic M cells in C. rodentium–infected mice at day (D) 6 and D10 after infection. Arrows indicate M cells. C: Representative confocal micrographs indicate the presence of dsRed+ M cells in the colonic epithelium of C. rodentium–infected mice at D6 and D10 after infection. Dotted lines indicate the epithelial basement membrane. D: M cell numbers quantified using whole mount tissue imaging. Graph shows M cell numbers increase at D6 and D10 after infection compared with naïve mice. Data are assessed by unpaired t-test. Data represent the means ± SEM (D). n = 3 mice per group (D). ∗∗P ≤ 0.01. PGRP-S, peptidoglycan recognition protein-short.