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. 2016 May;186(5):1114–1127. doi: 10.1016/j.ajpath.2015.12.017

Figure 1.

Figure 1

Galectin-3 immunohistochemistry in normal mouse tissues. A and B: In the mouse spleen (A) and liver (B), galectin-3 localizes in cells with morphologic characteristics of macrophages (arrows). C–H: Dual immunofluorescence for the anti–galectin-3 antibody Mac2 and CD68 localizes galectin-3 in liver (C–E) and spleen (F–H) macrophages (white arrows). I and J: However, in the bowel, galectin-3 staining also localizes in epithelial cells of the bowel lumen (I, arrows) and the serosa (J, arrows). Arrowheads show galectin-3+ cells with macrophage morphology in the bowel connective tissue. K: In the kidney, galectin-3 staining is noted in tubular epithelial cells (arrows). L–O: Serial section staining of sections from the mouse kidney (L and M) and bowel (N and O), localize galectin-3 immunoreactivity (L and N, arrows) in pancytokeratin+ epithelial cells (M and O, arrows). Counterstained with eosin. Scale bar = 60 μm.