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. 2016 May;186(5):1140–1150. doi: 10.1016/j.ajpath.2015.12.030

Figure 3.

Figure 3

Keratinocytes induce KRT9 through canonical activation of β-catenin. A: WNT5a and AXIN2 mRNA are elevated in co-culture with foreskin keratinocytes and plantar (sole) fibroblasts analyzed by quantitative RT-PCR. B: WNT5a and AXIN2 mRNA are induced in keratinocytes alone at higher cell densities and culture media conditions promoting differentiation in time-course experiments. C: mRNA of WNT5a is elevated in volar fibroblasts comparing with nonvolar fibroblasts. D: Active β-catenin protein, AXIN2 mRNA, and KRT9 mRNA and protein are induced with 5 μmol/L of SB216763, but not KRT6a mRNA. ∗P < 0.05, ∗∗P < 0.01. n = 3 (A); n = 3 to 6 (B); n = 3 to 4 (C); n = 3 to 5 (D). FrFB, foreskin; FtFB, dorsal foot; KRT, KERATIN; Precon, preconfluent keratinocytes only; ScFB, scalp; SoFB, sole fibroblast.