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. 2016 May 10;7:121. doi: 10.3389/fphar.2016.00121

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Copyright © 2016 Imbrici, Liantonio, Camerino, De Bellis, Camerino, Mele, Giustino, Pierno, De Luca, Tricarico, Desaphy and Conte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electrophysiological drug testing on expressed chloride channels and docking simulation. (A) Representative CLC-Ka patch-clamp recordings from transfected HEK293 cells, before and after the application of a synthetic compound, SRA-36. (B) Dose-response curve of CLC-Ka current inhibition by SRA-36 measured at +60 mV. (C) Model of the SRA-36 top-scored docking pose resulting from Induced Fit Docking simulations using a homology model of ClC-Ka modeled on the crystal structure of ClC-ec1.