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Average anti-GFP IgG ELISA titers after subcutaneous YCP-U65-GFP vaccination. Grey triangles: mice vaccinated with YCPs from ficin-treated cells. YCPs from cells processed at pH 11.5 gave very similar data. Open circles: mice vaccinated with YCPs from cells processed at pH 11.6. Mice vaccinated with YCPs from cells processed at pH 11.9 gave very similar data. The upper line, mice vaccinated with 4x doses of pH 11.9 YCPs.
