Table 2.

MicroRNAs CpG sites differentially methylated in Alzheimer's disease.

CpG probe ID	Chr: Start site	Associated gene	UCSC_RefGene_Group	Relation_to_CpG_Island	Enhancer	Control	AD	Delta beta	p value
cg22806002	11: 111383083	BTG4; MIR34C; MIR34B	TSS200; TSS1500; TSS1500	N_Shore	—	0.314 ± 0.005	0.358 ± 0.008	0.044 (4.4%)	0.0015
cg13149127	1: 156390835	C1orf61; MIR9-1	5′UTR; TSS1500	Island	TRUE	0.045 ± 0.001	0.055 ± 0.002	0.010 (1%)	0.0015
cg09994773	1: 9212514	MIR34A	TSS1500	“open sea”	—	0.826 ± 0.008	0.867 ± 0.011	0.041 (4.1%)	0.0057
cg16865908	11: 121970496	LOC399959; MIR125B1	Body; Body	“open sea”	TRUE	0.068 ± 0.007	0.109 ± 0.015	0.040 (4.0%)	0.0101
cg25851152	10: 10419537	MIR146B	TSS1500	S_Shelf	TRUE	0.072 ± 0.002	0.084 ± 0.002	0.011 (1.1%)	0.0101
cg09148270	11: 111384223	BTG4; C11orf88; MIR34C	TSS1500; TSS1500; Body	N_Shore	—	0.315 ± 0.010	0.372 ± 0.018	0.056 (5.6%)	0.0172
cg14278808	8: 9761141	LOC157627; MIR124-1	TSS1500; TSS200	Island	—	0.042 ± 0.002	0.051 ± 0.002	0.009 (0.9%)	0.0220
cg10822545	19: 13985513	MIR181D; MIR181C	TSS200; Body	S_Shore	—	0.833 ± 0.009	0.864 ± 0.007	0.031 (3.1%)	0.0220
cg02315626	17: 27188560	MIR451; MIR144	TSS200; Body	“open sea”	—	0.802 ± 0.011	0.841 ± 0.011	0.038 (3.8%)	0.0220
cg12530503	15: 89911148	MIR9-3	TSS200	Island	TRUE	0.129 ± 0.005	0.153 ± 0.007	0.024 (2.4%)	0.0349

AD = Alzheimer's disease; beta values are presented as means ± SEM; delta beta is the average of DNA methylation difference between the two compared groups; Mann-Whitney test, p values refer to the statistical analysis of the means of methylation levels from the two compared groups.