Table 2.
The effect of gentamicin (GM) on the serum levels of blood urea nitrogen (BUN), creatinine (Cr), malondialdehyde (MDA), kidney level of MDA, kidney tissue damage score (KTDS), body weight change (ΔBW), kidney weight (KW), and uterus weight (UW) in male and female rats.
| Gender | Group | BUN (mg/dL) | Cr (mg/dL) | Serum MDA (μmole/L) | Kidney MDA (nmole/g tissue) | KTDS | KW (g/100 g BW) | UW (g/100 g BW) | ΔBW (g) |
|---|---|---|---|---|---|---|---|---|---|
| Female | Control (group 1) |
21.79 ± 1.07 | 0.52 ± 0.08 | 5.49 ± 1.87 | 2.77 ± 0.20 | 0.33 ± 0.21 | 0.76 ± 0.02 | 0.02 ± 0.00 | 8.66 ± 1.68 |
| GM (group 2) |
38.57 ± 5.67∗ | 0.76 ± 0.10∗ | 6.83 ± 2.38 | 6.03 ± 1.10∗ | 1.8 ± 0.48∗ | 0.84 ± 0.04 | 0.01 ± 0.00∗ | 1.4 ± 2.48∗ | |
|
| |||||||||
| Male | Control (group 10) |
23.70 ± 2.39 | 0.59 ± 0.04 | 11.65 ± 1.20 | 2.12 ± 0.20 | 0.5 ± 0.28 | 0.74 ± 0.04 | — | 7.25 ± 6.36 |
| GM (group 11) |
34.27 ± 3.43∗ | 0.87 ± 0.09∗ | 6.88 ± 1.76∗ | 7.99 ± 2.23∗ | 1.2 ± 0.2∗ | 0.85 ± 0.07 | — | 1.8 ± 2.65 | |
∗ indicates significant difference from control group in each gender (P < 0.05).