Figure 2.

Schematic representation of chaperone and oxidoreduction activities during rotavirus entry. A: Cell surface reducing PDI has been shown to form complexes with integrins α2β1 and αvβ3 to generate free thiols in these integrins. Reducing integrin β3 can reduce thiol-disulfide bonds present in VP7; B: Chaperone activity of Hsc70 can induce conformational changes in VP5* and VP7 priming them for further interactions; C: Cell surface reducing PDI can reduce thiol-disulfide-containing VP5* and VP7 generating in them conformational changes needed for further interactions and entry. Hsc70: Heat shock cognate protein 70; PDI: Protein disulfide isomerase.