Table 2. Compartmental pharmacokinetic parameters of acacetin converted from acacetin prodrug (6 mg/kg, i.v.) in beagle dogs (n = 4, mean ± SEM).
| Pharmacokinetic parameters | Acacetin |
|---|---|
| K10_HL (min) | 12.8 ± 5.8 |
| Alpha (1/min) | 0.0800 ± 0.0735 |
| Beta (1/min) | 0.0 |
| A (ng/mL) | 2382 ± 3170 |
| B (ng/mL) | 5.10 ± 9.12 |
| CL (mL/min/kg) | 287 ± 103 |
| Vss (mL/kg) | 12526 ± 6338 |
| V2 (mL/kg) | 6609 ± 3230 |
K10_HL, a constant of elimination rate; Alpha, an initial phase of rapid decrease in plasma concentration; Beta, a phase of gradual decrease in plasma concentration after the alpha phase; CL, systemic clearance; VSS, apparent volume of distribution at steady-state; V2, apparent volume of distribution of peripheral compartment.