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. 2016 May 10;6:25616. doi: 10.1038/srep25616

Figure 4. UV irradiation decreases the expression of adiponectin and leptin receptors in the dermis and the subcutaneous (SC) fat tissues of the human skin in vivo.

Figure 4

Aged human (mean age 72.7 year; age range 70–75 years) buttock/forearm skin and young human (mean age 26.5 year; age range 21–33 years) buttock skin irradiated by 2 minimal erythema dose (MED) of ultraviolet (UV) light was obtained by punch biopsy, and SC fat tissues were separated from the dermis. (a–d) Adiponectin receptors (ADIPOR1 and ADIPOR2) and leptin receptor (LEPR) mRNA expression in the dermis (a,c) and in the SC fat tissues (b,d). Real-time PCR was used to determine mRNA of each gene (Data represent mean ± SEM of the ratio between each gene and 36B4. n = 3~5, *P < 0.05, **P < 0.01).