Table 1. Representative enriched categories with some of their DAP components.
| p value | UniProt | Protein name | Symbol | Zq | |
|---|---|---|---|---|---|
| Age comparison | |||||
| Extracellular matrix (GO:0031012) | 0.00 | P14780 | Matrix metalloproteinase-9 | MMP9 | 4.25 |
| Q12805 | EGF-containing fibulin-like extracellular matrix protein 1 | EFEMP1 | 3.54 | ||
| P55268 | Laminin subunit beta-2 | LAMB2 | 2.90 | ||
| P51888 | Prolargin | PRELP | 2.64 | ||
| P02462 | Collagen alpha-1(IV) chain | COL4A1 | 2.45 | ||
| P12110 | Collagen alpha-2(VI) chain | COL6A2 | 2.37 | ||
| Chromatin assembly or disassembly (GO:0006333) | 0.00 | P16401 | Histone H1.5 | HIST1H1B | −2.16 |
| P62805 | Histone H4 | HIST1H4A | −2.69 | ||
| Q02539 | Histone H1.1 | HIST1H1A | −3.04 | ||
| Mitochondrial part (GO:0044429) | 0.04 | Q8NC60 | Nitric oxide-associated protein 1 | NOA1 | −2.20 |
| P06241 | Tyrosine-protein kinase Fyn | FYN | −2.21 | ||
| P24310 | Cytochrome c oxidase subunit 7A1, mitochondrial | COX7A1 | −2.22 | ||
| Q9NS69 | Mitochondrial import receptor subunit TOM22 homolog | TOMM22 | −2.27 | ||
| P51970 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | NDUFA8 | −2.28 | ||
| P53007 | Tricarboxylate transport protein, mitochondrial | SLC25A1 | −2.42 | ||
| T2DM comparison | |||||
| Calcium ion binding (GO:0005509) | 0.00 | P06702 | Protein S100-A9 | S100A9 | 3.61 |
| P07996 | Thrombospondin-1 | THBS1 | 3.25 | ||
| P05109 | Protein S100-A8 | S100A8 | 3.05 | ||
| P55083 | Microfibril-associated glycoprotein 4 | MFAP4 | 2.81 | ||
| P13796 | Plastin-2 | LCP1 | 2.06 | ||
| P06703 | Protein S100-A6 | S100A6 | 2.02 | ||
| Mitochondrion (GO:0005739) | 0.00 | P99999 | Cytochrome c | CYCS | −2.01 |
| O75964 | ATP synthase subunit g, mitochondrial | ATP5L | −2.02 | ||
| P50213 | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | IDH3A | −2.04 | ||
| O75947 | ATP synthase subunit d, mitochondrial | ATP5H | −2.11 | ||
| Q5VTU8 | ATP synthase subunit epsilon-like protein, mitochondrial | ATP5EP2 | −2.12 | ||
| O75390 | Citrate synthase, mitochondrial | CS | −2.27 | ||
| Q02252 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial | ALDH6A1 | −2.27 | ||
| P05091 | Aldehyde dehydrogenase, mitochondrial | ALDH2 | −2.29 | ||
| Q5VT66 | Mitochondrial amidoxime-reducing component 1 | MARC1 | −2.43 | ||
| P38117 | Electron transfer flavoprotein subunit beta | ETFB | −2.44 | ||
| Gender comparison | |||||
| Inflammatory response (GO:0006954) | 0.00 | P02763 | Alpha-1-acid glycoprotein 1 | ORM1 | 5.44 |
| P04003 | C4b-binding protein alpha chain | C4BPA | 3.67 | ||
| P05155 | Plasma protease C1 inhibitor | SERPING1 | 3.15 | ||
| P10909 | Clusterin | CLU | 2.73 | ||
| P02751 | Fibronectin | FN1 | 2.42 | ||
| Oxidation reduction (GO:0055114) | 0.01 | P49327 | Fatty acid synthase | FASN | 5.59 |
| Q53TN4 | Cytochrome b reductase 1 | CYBRD1 | 4.35 | ||
| P00450 | Ceruloplasmin | CP | 4.21 | ||
| P07203 | Glutathione peroxidase 1 | GPX1 | 2.94 | ||
| O75891 | Cytosolic 10-formyltetrahydrofolate dehydrogenase | ALDH1L1 | 2.69 | ||
| P22352 | Glutathione peroxidase 3 | GPX3 | 2.03 | ||
| Oxidation reduction (GO:0055114) | 0.00 | P40939 | Trifunctional enzyme subunit alpha, mitochondrial | HADHA | −2.03 |
| Q13162 | Peroxiredoxin-4 | PRDX4 | −2.73 | ||
| P00441 | Superoxide dismutase [Cu-Zn] | SOD1 | −2.81 | ||
| P00352 | Retinal dehydrogenase 1 | ALDH1A1 | −3.08 | ||
| P07195 | L-lactate dehydrogenase B chain | LDHB | −3.09 | ||
| P21397 | Amine oxidase [flavin-containing] A | MAOA | −3.16 | ||
| P08294 | Extracellular superoxide dismutase [Cu-Zn] | SOD3 | −3.74 | ||
| Q92781 | 11-cis retinol dehydrogenase | RDH5 | −6.65 | ||
| Glutathione transferase activity (GO:0004364) | 0.00 | P09211 | Glutathione S-transferase P | GSTP1 | −2.35 |
| P28161 | Glutathione S-transferase Mu 2 | GSTM2 | −2.55 | ||
| P30711 | Glutathione S-transferase theta-1 | GSTT1 | −3.49 | ||
| P09488 | Glutathione S-transferase Mu 1 | GSTM1 | −5.63 | ||
Functional categories were retrieved from the DAVID database. The p value for each term is shown. Relative abundance change of proteins is indicated with the corresponding Zq value for each comparison. These values can also be found in the extended Supplementary Table S3, where a colour scale in red and blue colours is represented for up- and down-regulated proteins, respectively.